Vascular Supporting Functions of MSC (Collaborative Research Between KSU and KMEB)

May Al-Nbaheen

Laboratory Manager
Stem Cell Unit, Anatomy Department

Medical College, King Saud University

Abstract

Peripheral artery disease is a painful vascular disease caused by a narrowing or blockage of any blood vessel outside the heart or brain but most often occurs in the legs. Patients suffering from PAD have an increased risk of heart attack or stroke.

Our laboratory has described Adult Stem Cells can be isolated from Adipose tissue,
And it has the similar properties of the Bone Marrow Derived Mesenchymal Stem Cells.
We compared MSCs derived from AT with BM, this source regarding morphology, the success rate of isolating MSCs, colony frequency, expansion potential, multiple differentiation capacity, and immune phenotype. No significant differences concerning the morphology, immune phenotype and gene profile of the MSCs derived from this source was obvious. Differences could be observed concerning the success rate of isolating MSCs, which was 100% for BM and AT.

Laboratory testing provides hope that new blood vessels will develop from the injection of adult stem cells, when MSCs are differentiated in to Vascular via Endothelial Differentiation.

One day, stem cells may enable the targeted delivery of cellular treatments to PAD patients who may be facing amputation and death. It will be important to deliver the right amount of drug treatment to the right place, thus allowing tailored treatment for individual patients